Effect of recombinations on changes in genotype proportions between norovirus seasons in Japan
نویسندگان
چکیده
Norovirus (NoV) is an etiological agent of acute gastroenteritis in humans. Genomic recombinations NoV occur mainly at the junction genes encoding RNA-dependent RNA polymerase (RdRp) and major capsid protein (viral 1, VP1), which may produce strains with novel combinations VP1- RdRp-genotypes. Here effect on changes proportions VP1-genotypes was examined through analysis observed frequencies Japan from season 2006/2007 to 2019/2020 reported Infectious Agents Surveillance Report (IASR) nucleotide sequences for 2788 GI 19,782 GII deposited International Nucleotide Sequence Database (INSD). Positive correlation identified between frequency IASR number INSD individual each season. In addition, acquisition RdRp-genotypes associated increase proportion VP1-genotypes. Recombinations creating be adaptive mechanism NoV.
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ژورنال
عنوان ژورنال: Meta Gene
سال: 2021
ISSN: ['2214-5400']
DOI: https://doi.org/10.1016/j.mgene.2021.100934